SrasV1, Main, Exploration, bibRecord, 002121

Emodin inhibits current through SARS-associated coronavirus 3a protein.

Identifieur interne : 002121 ( Main/Exploration ); précédent : 002120; suivant : 002122

Emodin inhibits current through SARS-associated coronavirus 3a protein.

Auteurs : Silvia Schwarz [République populaire de Chine] ; Kai Wang ; Wenjing Yu ; Bing Sun ; Wolfgang Schwarz

Source :

Antiviral research [ 1872-9096 ] ; 2011.

RBID : pubmed:21356245

Descripteurs français

KwdFr :
- Antiviraux (pharmacologie), Humains, Libération de particules virales (), Lignée cellulaire, Protéines virales (antagonistes et inhibiteurs), Virus du SRAS (), Virus du SRAS (physiologie), Émodine (pharmacologie).
MESH :
- antagonistes et inhibiteurs : Protéines virales.
- pharmacologie : Antiviraux, Émodine.
- physiologie : Virus du SRAS.
- Humains, Libération de particules virales, Lignée cellulaire, Virus du SRAS.

English descriptors

KwdEn :
- Antiviral Agents (pharmacology), Cell Line, Emodin (pharmacology), Humans, SARS Virus (drug effects), SARS Virus (physiology), Viral Proteins (antagonists & inhibitors), Virus Release (drug effects).
MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , pharmacology : Antiviral Agents, Emodin.
- drug effects : SARS Virus, Virus Release.
- physiology : SARS Virus.
- Cell Line, Humans.

Abstract

The open-reading-frame 3a of SARS coronavirus (SARS-CoV) had been demonstrated previously to form a cation-selective channel that may become expressed in the infected cell and is then involved in virus release. Drugs that inhibit the ion channel formed by the 3a protein can be expected to inhibit virus release, and would be a source for the development of novel therapeutic agents. Here we demonstrate that emodin can inhibit the 3a ion channel of coronavirus SARS-CoV and HCoV-OC43 as well as virus release from HCoV-OC43 with a K1/2 value of about 20 μM. We suggest that viral ion channels, in general, may be a good target for the development of antiviral agents.

DOI: 10.1016/j.antiviral.2011.02.008
PubMed: 21356245

Affiliations:

République populaire de Chine

Le document en format XML

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<front><div type="abstract" xml:lang="en">The open-reading-frame 3a of SARS coronavirus (SARS-CoV) had been demonstrated previously to form a cation-selective channel that may become expressed in the infected cell and is then involved in virus release. Drugs that inhibit the ion channel formed by the 3a protein can be expected to inhibit virus release, and would be a source for the development of novel therapeutic agents. Here we demonstrate that emodin can inhibit the 3a ion channel of coronavirus SARS-CoV and HCoV-OC43 as well as virus release from HCoV-OC43 with a K1/2 value of about 20 μM. We suggest that viral ion channels, in general, may be a good target for the development of antiviral agents.</div>
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Emodin inhibits current through SARS-associated coronavirus 3a protein.

Emodin inhibits current through SARS-associated coronavirus 3a protein.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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